Good Example Of Drug Delivery Essay

Drug delivery is directed transport of the drug substance in a predetermined area of an organism, organ or cell. In this essay we will discuss nanotechnology of drug delivery in cardiology practice.
The term "nanotechnology" was proposed in 1974 by a Japanese scientist Norio Taniguchi and apply in relation to objects the size of 10.09 meters (from 1 to 100 nm) . And if in the middle of the twentieth century, it seemed more perspective, look to the future, now is the reality of life. A wide interest in the products of nanotechnology in medicine is due to the possibility of their use for diagnosis, treatment and prevention of various diseases. As part of this publication is not possible to cover all aspects of the application of nanotechnology in medicine, so consider it appropriate and interesting for the audience practical application of nano lighting issue in cardiology.
For many decades conducted (and do not stop till now) searching for the ideal drug delivery systems, which is quite understandable and objective factors. As is known, the disease affects primarily the individual organs and tissues. For example, in myocardial infarction major events occur in the heart muscle, with inflammation - in specific target organs. Therefore, the duration of treatment and its success is directly dependent on the implementation of the action of drugs directly to the outbreak of the disease. This is especially important in cases where the treatment occurs in the need for highly toxic drugs effective against the disease, but has toxic effects on other body systems. Often this leads to abandon the use of such substances, and to resort to the use of less effective drugs.
Create the desired concentration of drug in the diseased areas without affecting the others is a difficult task. After all medicines in whatever way they were administered either distributed throughout the body more or less evenly. And for that they were in the pathological focus, you need a carrier that delivered the drugs to their destination. Therefore, the search for such ideal carrier continues to this day.
The most common nanoparticles used in drug delivery are liposomes. During the study of liposome found that empty space inside the liposomes can be filled with any substance. The ability of liposomes to include a variety of substances practically without any limitation gave a unique opportunity to address many medical problems. Liposomes can be filled with antibiotics, hormones, enzymes, immunomodulators, cytotoxic agents, antiviral and antifungal agents, vitamins, vaccines, substances metabolic actions and even genetic material.
Liposomes help to maintain a high level of concentration of drugs in blood and in cells as well as promote better penetration of the drug in those areas where they are not liposomes cannot penetrate. Currently, this is perhaps the most rapidly developing areas of the practical use of these nanoparticles in drug delivery.Works Cited
Hoffman Allan S. The origins and evolution of “controlled” drug delivery systems // J. Contr. Release. 2008. V. 132. P. 153—163.
Nanoparticulate Drug Delivery Systems / Ed. by D. Thassu, M. Deleers, Y. Pathak. — Informa Healthcare, 2007. — 352 p.
Bertrand N, Leroux JC. (2011). "The journey of a drug carrier in the body: an anatomo-physiological perspective". Journal of Controlled Release 161 (2): 152–63. doi:10.1016/j.jconrel.2011.09.098. PMID 22001607.